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Biosynthetic clusters of secondary metabolite genes identified in the genome of Bacillus subtilis strain 200
(Odesa I. I. Mechnikov National University, 2024) Aleksandrovych, D.; Vasylieva, Nataliia Yu.; Александрович, Д.; Васильєва, Наталія Юріївна
The Bacillus subtilis 200 strain, isolated from a sample of bottom sediments of the anaerobic zone of the Black Sea, demonstrated antagonistic activity against Pseudomonas aeruginosa, Escherichia coli, Salmonella enterica, Klebsiella pneumoniae and Bacillus subtilis, especially high against Proteus vulgaris, Staphylococcus aureus, Bacillus cereus and Candida albicans. After analyzing the genome of Bacillus subtilis 200 on the antiSMASH server, 15 regions were identified in which secondary metabolites are produced. Most of the clusters belong to the NRPS and PKS type. This strain is capable of synthesizing a variety of secondary metabolites such as terpenes, glycocins, metallophores, subtylosin-A, taililanstatin A, bacillisin, and surfactin. Thus, the Bacillus subtilis 200 strain produces many secondary metabolites with a wide spectrum of biological activity, which can be used in the production of new drugs.