Toxicity and antiviral action of the aminomethanesulphonic acid and its N-alkylated derivatives

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dc.contributor.authorKhoma, Ruslan Ye.en
dc.contributor.authorEnnan, Alim-Abdul A.en
dc.contributor.authorGodovan, V. V.en
dc.contributor.authorAntonenko, P. B.en
dc.contributor.authorGrydina, T. L.en
dc.contributor.authorFedchuk, Alla S.en
dc.contributor.authorLozitsky, Viktor P.en
dc.contributor.authorХома, Руслан Євгенійовичuk
dc.date.accessioned2018-03-20T10:00:04Z
dc.date.available2018-03-20T10:00:04Z
dc.date.issued2016
dc.description.abstractThe influenza is the most mass disseminated viral disease of the human respiratory. The purpose of this study is to research toxicity and antiviral activity of the aminomethanesulphonic acid (I) and its N-methyl (II), N-tert-butylderivatives (III) and reference drug (Tamiflu). We have determined the maximally tolerant (non-toxic) doses (MTD) for these compounds. Oral LD50 of I – III: > 5000 mg/kg (rat, male) – practically non-toxic. On tissue culture CAC influenza activity was determined in a dose of 10-3 M as for test compounds so for the reference drug (Tamiflu).en
dc.identifier.citationProgram and Abstract of 29th International Conference on Antiviral Research (ICAR). – 2016. – 17-21 April 2016.
dc.identifier.urihttps://dspace.onu.edu.ua/handle/123456789/13129
dc.language.isoen
dc.subjectaminomethanesulphonic aciden
dc.subjecttoxicityen
dc.subjectantiviral actionuk
dc.titleToxicity and antiviral action of the aminomethanesulphonic acid and its N-alkylated derivativesen
dc.typeArticle
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