Toxicity and antiviral action of the aminomethanesulphonic acid and its N-alkylated derivatives
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2016
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The influenza is the most mass disseminated viral disease of the human respiratory. The purpose of this study is to research toxicity and antiviral activity of the aminomethanesulphonic acid (I) and its N-methyl (II), N-tert-butylderivatives (III) and reference drug (Tamiflu). We have determined the maximally tolerant (non-toxic) doses (MTD) for these compounds. Oral LD50 of I – III: > 5000 mg/kg (rat, male) – practically non-toxic. On tissue culture CAC influenza activity was determined in a dose of 10-3 M as for test compounds so for the reference drug (Tamiflu).
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aminomethanesulphonic acid, toxicity, antiviral action
Бібліографічний опис
Program and Abstract of 29th International Conference on Antiviral Research (ICAR). – 2016. – 17-21 April 2016.