Desensitization of prostatisis sufferers using immunogen-conjugated Chlamydophila psittaci vaccine
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Дата
2024
Науковий керівник
Укладач
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Видавець
ДУ ІПЕП
Анотація
In cases when prostatitis sufferers have inflammation of Chlamydia trachomatis origin, they require immune protection against Chlamydial infection. We are published the biotechnological properties of an immunogen conjugated cultural vaccine used for chronic prostatitis sufferers. The vaccine was prepared from Chlamydophila psittaci. The antigenic properties of Chlamydia trachomatis and Chlamydophila psittaci have similar genus-specific antigenes. Since Chlamydia trachomatis has toxicity and is not immunogenic, we used our own isolated strain of Chlamydophila psittaci. To eliminate infectivity, we modified the strain using ultraviolet (UV) radiation. To increase immunogenicity, we used a biopeptide, the amino acid methionine. To confirm Chlamidial origin of inflammation, we cultured samples from chronic prostatitis sufferers, including: expressed prostatic secretion (EPS), sperm and urethral swab. Chlamydia was isolated in cell culture: McCoy, NCTC L-929. After confirming the cause of inflammation, it was necessary to test each sufferer's lymphocyte sensitivity to Chlamydial antigene. If lymphocyte inhibition is more than 8%, desensitization of the sufferer's body is necessary first. Antibody levels may be found in chronic prostatitis sufferers with either no history of chlamydial infection or those with past infection. A single specimen endpoint titer of 1:64 to 1:512 should be considered evidence of infection at an undetermined time. Antibodies against Chlamydia can persist for a long time, sometimes month or even years, yet this does not indicate an active infection. Chlamydia antibody detected decreases with time since infection, most notable in the first six months.
Опис
Ключові слова
chronic prostatitis, desensitization, chlamydial vaccine, cell culture
Бібліографічний опис
Bayraktar V. M. Desensitization of prostatisis sufferers using immunogen-conjugated Chlamydophila psittaci vaccine / V. M. Bayraktar // Ендокринна патологія у віковому аспекті : матеріали наук.-практ. конф. з онлайн-трансляцією (Харків, 21-22 листоп. 2024 р.). – Харків : ДУ ІПЕП, 2024. – С. 15–17.