Генетичні аспекти тромботичних ускладнень у вагітних
Альтернативна назва
Genetic aspects of thrombotic complications in pregnant women
Ескіз недоступний
Дата
2018
Автори
Науковий керівник
Укладач
Редактор
Назва журналу
ISSN
E-ISSN
Назва тому
Видавець
Одеський національний університет імені І. І. Мечникова
Анотація
Проведено дослідження 186 вагітніх жінок на прояв тромбофілії. Визначено частоту стрівальності даного захворювання, складено родоводи, а також досліджено фенотиповий прояв тромбофілії та проведено молекулярно-генетичний аналіз захворювання...
186 pregnant women were examined for thrombophilic manifestations. The frequency of morbidity of this disease was determined, pedigree was made, and the phenotypic manifestation of thrombophilia was investigated and a molecular genetic analysis of the disease was conducted. It was found that the risk of thrombosis in pregnant women with hereditary forms of thrombophilia and concomitant varicose veins is twice as high as in women without vein disease and is respectively 45.8 % and 24.3 %. The main forms of thrombosis in pregnant women are deep vein thrombosis, surface vein thrombosis, pulmonary artery thromboembolism, acute cerebrovascular accident, which may occur during pregnancy and in the postpartum period. Using PCR in pregnant women with hereditary thrombophilia, the following mutations were identified: MTHFR, Leiden Factor V, prothrombin F2, and PAI 1.
186 pregnant women were examined for thrombophilic manifestations. The frequency of morbidity of this disease was determined, pedigree was made, and the phenotypic manifestation of thrombophilia was investigated and a molecular genetic analysis of the disease was conducted. It was found that the risk of thrombosis in pregnant women with hereditary forms of thrombophilia and concomitant varicose veins is twice as high as in women without vein disease and is respectively 45.8 % and 24.3 %. The main forms of thrombosis in pregnant women are deep vein thrombosis, surface vein thrombosis, pulmonary artery thromboembolism, acute cerebrovascular accident, which may occur during pregnancy and in the postpartum period. Using PCR in pregnant women with hereditary thrombophilia, the following mutations were identified: MTHFR, Leiden Factor V, prothrombin F2, and PAI 1.
Опис
Ключові слова
6.040102 біологія, тромбофілія вагітних, успадковування, гени, pregnancy thrombophilia, inheritance, genes
Бібліографічний опис
Татарчук, І. О. Генетичні аспекти тромботичних ускладнень у вагітних = Genetic aspects of thrombotic complications in pregnant women : дипломна робота бакалавра / І. О. Татарчук; наук. кер. С. Л. Мірось; ОНУ ім. І.І. Мечникова, Біол. ф-т, Каф. генетики та молекулярної біології. – Одеса, 2018. – 41 с.