Стан кісткової системи щурів за умов гипотеріозу та його корекції
Вантажиться...
Дата
2019
Науковий керівник
Укладач
Редактор
Назва журналу
ISSN
E-ISSN
Назва тому
Видавець
Одеський національний університет імені І. І. Мечникова
Анотація
При зміні функції щитовидної залози відбувається порушення процесів кісткового ремоделювання. В літературі є багато інформації, про те що гіпертиреозможе призводити до зниження щільності кісткової тканини і зменшення її міцності, тобто до розвитку остеопорозу. При цьому дослідження з приводу вираженості і характеру змін кісткової структури у осіб з гіпотиреозом, як при вперше виявлених нелікованих формах, так і на фоні тривалої замісної терапії тиреоїдними гормонами суперечливі. Серед маркерів метаболізму кісткової тканини використовуються показники активності фосфатаз: активність лужної фосфатази (ЛФ)трактується як показник формування, а кислої фосфатази (КФ) як показник резорбції кісткової тканини.
Research on the severity and nature of changes in bone structure in patients with hypothyroidism rather contradictory. Therefore the purpose of the research was to determine the activity of alkaline and acidic phosphatases in the femoral bone of rats under conditions of hypothyroid modeling and its correction. During the investigation was determined that activity acidic phosphatase in femur in rats with hypothyroidism was 2.6 times higher, and in animals treated with prophylactic drugs against the background of hypothyroidism − 8.5 times than in intact animals. In determining the activity of this enzyme in serum of rats with hypothyroidism and his correction there were no significant changes in the activity of acid phosphatase relative to the control data. Determination of alkaline phosphatase in the femoral bone showed no significant changes in the indices of animals with hypothyroidism, and in rats receiving prophylactic preparations the enzyme activity increased 3.4 times. In the serum of rats with hypothyroidism, the activity of alkaline phosphatase decreased by 1.6 times, and the group with correction, on the contrary, increased 2-fold, than in the intact group. Calculation of the coefficient of mineralization (alkaline phosphatase / acid phosphatase) which reflects the degree of bone mineralization showed that intact group it was 2 times higher than in the experimental groups. Thus, the research showed a change in the activity of bone isoforms of acid phosphatase and alkaline phosphatase in the design of mercazolyl hypothyroidism. Deficiency of thyroid hormones led to initial changes in bone tissue, which manifested by increased resorption and decreased remodeling.
Research on the severity and nature of changes in bone structure in patients with hypothyroidism rather contradictory. Therefore the purpose of the research was to determine the activity of alkaline and acidic phosphatases in the femoral bone of rats under conditions of hypothyroid modeling and its correction. During the investigation was determined that activity acidic phosphatase in femur in rats with hypothyroidism was 2.6 times higher, and in animals treated with prophylactic drugs against the background of hypothyroidism − 8.5 times than in intact animals. In determining the activity of this enzyme in serum of rats with hypothyroidism and his correction there were no significant changes in the activity of acid phosphatase relative to the control data. Determination of alkaline phosphatase in the femoral bone showed no significant changes in the indices of animals with hypothyroidism, and in rats receiving prophylactic preparations the enzyme activity increased 3.4 times. In the serum of rats with hypothyroidism, the activity of alkaline phosphatase decreased by 1.6 times, and the group with correction, on the contrary, increased 2-fold, than in the intact group. Calculation of the coefficient of mineralization (alkaline phosphatase / acid phosphatase) which reflects the degree of bone mineralization showed that intact group it was 2 times higher than in the experimental groups. Thus, the research showed a change in the activity of bone isoforms of acid phosphatase and alkaline phosphatase in the design of mercazolyl hypothyroidism. Deficiency of thyroid hormones led to initial changes in bone tissue, which manifested by increased resorption and decreased remodeling.
Опис
Ключові слова
гіпотиреоз, кісткова тканина, лужна фосфатаза, кисла фосфатаза
Бібліографічний опис
Збірка матеріалів наукового товариства студентів, аспірантів і молодих вчених. – Одеса: Репозитарій наукової бібліотеки ОНУ імені І.І. Мечникова, 2019.