Перегляд за Автор "Grydina, T. L."

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    Toxicity and antiviral action of the aminomethanesulphonic acid and its N-alkylated derivatives
    (2016) Khoma, Ruslan E. ; Ennan, Alim-Abdul A.; Godovan, V. V.; Antonenko, P. B.; Grydina, T. L.; Fedchuk, Alla S.; Lozitsky, Viktor P.; Хома, Руслан Євгенійович
    The influenza is the most mass disseminated viral disease of the human respiratory. The purpose of this study is to research toxicity and antiviral activity of the aminomethanesulphonic acid (I) and its N-methyl (II), N-tert-butylderivatives (III) and reference drug (Tamiflu). We have determined the maximally tolerant (non-toxic) doses (MTD) for these compounds. Oral LD50 of I – III: > 5000 mg/kg (rat, male) – practically non-toxic. On tissue culture CAC influenza activity was determined in a dose of 10-3 M as for test compounds so for the reference drug (Tamiflu).