Перегляд за Автор "Fedchuk, Alla S."

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  • Ескіз
    Документ
    Anti-Influenza Activity of Argentums Bis(citrato)Germanate
    (2016) Seifullina, Inna Y.; Martsynko, Olena E.; Chebanenko, Olena Anatoliivna; Grydina, Tetiana Leonidivna; Fedchuk, Alla S.; Mudryk, L.; Radkevich, K. V.; Марцинко, Елена Эдуардовна; Марцинко, Олена Едуардівна; Сейфулліна, Інна Йосипівна; Сейфуллина, Инна Иосифовна
    The creation of the needed chemical-therapeutic reserve which could provide the prophylactics and treatment in the case of the significant increase of influenza infected persons is the actual task of the contemporary medical science. Now intensively studied properties of metal complexes for detection of new biological properties to create a new anti-infection drugs. New coordination compounds of cobalt bis(cltrato)germanate (Ge) and cobalt bls(citrato)stannate (Sn) have a low toxic that gives the prospect for further research and implementation In medical practice.
  • Ескіз
    Документ
    Anti-influenza activity of the N-benzylaminomethansulphonic acid
    (2017) Khoma, Ruslan E.; Ennan, Alim-Abdul A.; Grydina, Tetiana L.; Radkevich, K. V.; Fedchuk, Alla S.; Lozitsky, Viktor P.; Хома, Руслан Євгенійович
    The influenza virus causes the greatest number of acute respiratory viral infections, which can lead to an exacerbation of chronic systemic diseases, to emergence of bacterial complications, to a significant deterioration of public health. But the majority of human isolates of influenza viruses rapidly become resistant to remantadine, oseltamivir. So, the creation of new effective anti-influenza agents is urgent task of medical science.
  • Ескіз
    Документ
    Toxicity and antiviral action of the aminomethanesulphonic acid and its N-alkylated derivatives
    (2016) Khoma, Ruslan E. ; Ennan, Alim-Abdul A.; Godovan, V. V.; Antonenko, P. B.; Grydina, T. L.; Fedchuk, Alla S.; Lozitsky, Viktor P.; Хома, Руслан Євгенійович
    The influenza is the most mass disseminated viral disease of the human respiratory. The purpose of this study is to research toxicity and antiviral activity of the aminomethanesulphonic acid (I) and its N-methyl (II), N-tert-butylderivatives (III) and reference drug (Tamiflu). We have determined the maximally tolerant (non-toxic) doses (MTD) for these compounds. Oral LD50 of I – III: > 5000 mg/kg (rat, male) – practically non-toxic. On tissue culture CAC influenza activity was determined in a dose of 10-3 M as for test compounds so for the reference drug (Tamiflu).