Перегляд за Автор "Ruschak, Olga V."

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    Influence of New N-Methylquinolinyl Porphyrins on Different Candida albicans Development Forms
    (2017) Rusakova, Mariia Yu.; Ruschak, Olga V.; Vodzinskyi, Serhii V.; Ishkov, Yurii V.; Русакова, Мария Юрьевна; Рущак, Ольга Васильевна; Водзинский, Сергей Валентинович; Ишков, Юрий Васильевич; Ішков, Юрій Васильович; Русакова, Марія Юріївна
    The activity of new N-methylquinolinyl porphyrins against different morphological forms of Candida albicans (unattached, free-dividing cells, as well as structures formed in the process of biofilm maturation) was characterized. Modification of porphyrin molecules by N-methyl-6-quinolinyl increases the fungicidal effect on the yeast cells, in contrast to N-methyl-7-quinolinyl derivatives that are effective against hyphal structures. Candida albicans biofilm cells are more resistant to low concentrations of the studied compounds however the significant inhibition of the microbial community is in the presence of 1 μM.