Перегляд за Автор "Ovchinnikov, S."

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  • Ескіз
    Документ
    Antimicrobial properties of some porphyrin compounds against catheter related infections
    (Одеський національний університет імені І. І. Мечникова, 2018) Barlit, H.; Ovchinnikov, S.; Rusakova, Mariia Yu.; Русакова, Марія Юріївна; Русакова, Мария Юрьевна
    Central venous access is commonly used in clinical practice for a wide spectrum of procedures. The main complications limiting use of central and peripheral catheters include catheter-related infections. The epidemic of microbial resistance to widely-used antibiotic groups seriously complicates treatment of CRI even in complex with systemic antibiotic therapy. In this paper we propose to consider porphyrin compounds as alternative antimicrobial agents for antimicrobial lock therapy. It was discovered antimicrobial action of porphyrin compounds against S. aureus and E. coli that was significantly enhanced in composition with EDTA as additional component of antimicrobial lock solution
  • Ескіз
    Документ
    The anti-candida activity of new n-methylquinolinyl- porphyrins in vitro
    (Odessa I. I. Mechnikova National University, 2017) Ovchinnikov, S.; Vasyil'yev, M.; Rusakova, Mariia Yu.; Русакова, Мария Юрьевна; Русакова, Марія Юріївна
    The activity of new N-methyl-quinolinyl-porphyrins against different morphological forms of Candida albicans (unattached, freedividing cells, as well as structures formed in the process of biofilm maturation) was characterized. Modification of porphyrin molecules by N-methyl-6-quinolinyl increases the fungicidal effect on the yeast cells, in contrast to N-methyl-7-quinolinyl derivatives that are effective against hyphal structures. Candida albicans biofilm cells are more resistant to low concentrations of the studied compounds.
  • Ескіз
    Документ
    The influence of some synthetic porphyrins on the culture of Candida albicans
    (Odesa I. I. Mechnikov National University, 2016) Ovchinnikov, S.; Vasyil'yev, M.; Rusakova, Mariia Yu.; Русакова, Марія Юріївна; Русакова, Мария Юрьевна
    Porphyrins are macroheterocyclic compounds, containing conjugated system, which is based on four pyrrole rings linked by four methine groups in α-positions. Two classes of porphyrins, natural and synthetic, can be distinguished on the basis of their origin and structure (Soman R., 2015).