Репозитарій ОНУ імені І.І.Мечникова

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Antagonistic effect of actinobacteria isolated from sponges Haliclona sp. on indicator strains of pro- and ukaryotic microorganisms
(Odesa I. I. Mechnikov National University, 2024) Mashkova, A.; Strashnova, Iryna V.; Машкова, А.; Страшнова, Ірина Валентинівна
Studies of representatives of the Actinobacteria phylum remain relevant as the largest and most promising source of new antibiotic compounds. The aim of the study was to investigate the antagonistic activity of actinobacteria isolated from Haliclona sp. sponges against indicator strains of pro- and eukaryotic microorganisms. The antagonistic activity of 14 isolated strains of actinobacteria was determined by the block method after their preliminary cultivation on agarized medium Gauze 2. The antagonistic effect of actinobacteria was determined against 12 strains of indicator pro- and eukaryotic microorganisms. Almost all of the studied strains of isolated actinobacteria inhibited the growth of at least one strain of the indicator microorganism. The most sensitive to secondary metabolites of actinobacteria were indicator strains of all gram-positive bacteria, as well as Pseudomonas aeruginosa ATCC 27853 and Candida albicans ATCC 18804. Strains Actinobacteria Hal 2, Hal 4 and Hal 14 showed the best antagonistic activity against indicator microorganisms, which were selected for further studies.