Galkin, Mykola B.Semenets, Anastasiia S.Finogenova, M. O.Галкін, Микола Борисович2019-02-262019-02-262018The Ukrainian biochemical journalhttps://dspace.onu.edu.ua/handle/123456789/22166Pseudomonas aeruginosa is a Gram-negative pathogen responsible for a variety of opportunistic infections, including chronic airway infections in patients with cystic fibrosis (CF). During the course of chronic infection, P. aeruginosa forms matrix-encased, surface-associated communities called biofilms. Biofilms are thought to contribute to persistence in the CF airway by contributing to evasion of the host immune response and antimicrobial therapy. Biofilm communities differ from planktonic bacterial cultures not only in terms of their metabolic activity but they also display stage-specific phenotypes during development and considerable spatial heterogeneity of physiological condition. Cells alter the fatty acid composition of their lipids to maintain membrane fluidity with varying environmental conditions. In this study, fatty acid profiles of biofilms versus planktonic cells of the P. aeruginosa with different level of intracellular c-di-GMP were compared.enPseudomonas aeruginosac-di-GMPmetabolic activityArticle