Bayraktar, Vasyl M.Байрактар, Василь Миколайович2025-04-232025-04-232024Bayraktar V. M. Activity of Herpes simplex virione vaccine for men after formaldehyde neutralization / V. M. Bayraktar // Механізми розвитку патологічних процесів і хвороб та їх фармакологічна корекція : матеріали 7 наук.-практ. Internet-конф. з міжнар. участю (Харків, 14 листоп. 2024 р.) [Mechanisms of pathological processes development and diseases, their pharmacological correction : collected papers of to the 7th scientific and practical internet-conference for the international participation (Kharkiv, 14 November 2024)]. – Харків : НФаУ, 2024 [Kharkiv : NUPh, 2024.]. – С. 33–37 [P. 33–37].https://dspace.onu.edu.ua/handle/123456789/41094Formaldehyde in viral vaccines coagulates proteins and prevents their decomposition. For inactivation of virione herpes simplex vaccine, sulfitization is necessary to neutralize formaldehyde. A small amount of 0,2% of formaldehyde is used from pure, 37% stock concentration. Herpes simplex virone vaccine stimulatates cellular mechanisms of resistance in the human body against herpes simplex virus types I and II. It increases the activity of white blood cells and lymphocytes, thereby suppressing the herpes simplex virus in up to 87% of cases permanently. The vaccine against herpes simplex virus stimulates and increases after specific vaccination 30-60 days after specific vaccination, raising blood levels of specific antibodies which suppress viral activity. The virus enters a dormant state, resulting in reduced skin rashes, mucosal ulcers, ophthalmic herpes, and genital herpes. Frequently after vaccination, herpes simplex virus type 1 and 2 symptoms completely disappear. However, before starting vaccination, the patient must undergo a blood test to check immune status, including sensitivity of lymphocytes to herpes simplex virus. If percentage of inhibition is more than 8%, intradermal pure vaccine injection is contraindicated, as the patient's body Because body is sensitized to herpes simplex virus. In this case, the vaccine must be deluted three time and requires initial desensitization of the body.enformaldehydeantibody titreherpes simplex virusvirione vaccineformaldehyde concentrationneutralization of formaldehydetitre of antibodyArticle