Lisova, O. O.Finogenova, M. O.Semenets, Anastasiia S.2017-11-272017-11-272016"Molecular microbiology and biotechnology", International scientific conference": abstracts, Odessa, Ukraine, June 21-23, 2016 / Odessa I.I. Mechnikov national univ. ; Chairman: V. O. Ivanytsia [et al.] . – Odessa, 2016.https://dspace.onu.edu.ua/handle/123456789/11554С-di-GMP controls the switch between motile and sessile lifestyles: high cellular levels of c-di-GMP promote exopolysaccharides production and surface adhesion, leading to biofilm formation; on the other hand, low c-di-GMP levels result in flagellar gene-expression and increased cellular motility (RÖmling et al., 2013). Antimicrobial therapy has played a crucial role in the treatment of infectious diseases in humans in XX century, as the use of antibiotics significantly reduced mortality from infection.enPseudomonas aeruginosaPseudomonasaeruginosaArticle