Gordievskaya, Т. V.Vasylieva, Nataliia Yu.Yamborko, Hanna V.Васильєва, Наталія ЮріївнаЯмборко, Ганна Валентинівна2019-12-022019-12-022019Modern problems of microbiology and biotechnology : intern. conf. of young scientists : materials, 18th - 21st June 2019, Odesahttps://dspace.onu.edu.ua/handle/123456789/26350Currently, the use of antibiotics for the treatment of most diseases leads to the emergence of the so-called "multiple resistance" in pathogens, which significantly reduces the effectiveness of treatment. Therefore, controlling infections through a nonantibiotic approach is urgently needed. The potential use of Lactobacillus to control typhoid fever represents a promising approach, as it may exert protective actions through various mechanisms. Lactobacilli have a long history of safe use, especially in the dairy industry [3]. Different Lactobacillus strains can function as microbial barriers against * gastrointestinal pathogens through competitive exclusion of pathogen binding, , modulation of the host's immune system, and production of inhibitory compounds, . such as organic acid (e.g., lactic acid and acetic acid), oxygen catabolites (e.g., hydrogen peroxide), proteinaceous compounds (e.g., bacteriocins) and etc [4; 5; 7; 10]. Herewith, the combination of different strains among themselves in different proportions allows to achieve the best result.enantibioticcontrolling infectionsLactobacillusSalmonella entericaDevelopment of Lactobacillus strains composition for enhancing of antagonistic activity against Salmonella entericaArticle