Barlit, H.Ovchinnikov, S.Rusakova, Mariia Yu.Русакова, Марія ЮріївнаРусакова, Мария Юрьевна2018-12-192018-12-192018Modern problems of Microbiology and Biotechnology: materials of M78 young scientists international conference (Odesa, 20-23 june 2018). – Odesa : «Odesa I. I. Mecnikov National University», 2018.https://dspace.onu.edu.ua/handle/123456789/20687Central venous access is commonly used in clinical practice for a wide spectrum of procedures. The main complications limiting use of central and peripheral catheters include catheter-related infections. The epidemic of microbial resistance to widely-used antibiotic groups seriously complicates treatment of CRI even in complex with systemic antibiotic therapy. In this paper we propose to consider porphyrin compounds as alternative antimicrobial agents for antimicrobial lock therapy. It was discovered antimicrobial action of porphyrin compounds against S. aureus and E. coli that was significantly enhanced in composition with EDTA as additional component of antimicrobial lock solutionenporphyrinscatheter-related infectionslock therapybiofilmArticle