Шматкова, Наталья ВладимировнаЗинченко, Оксана ЮрьевнаСейфуллина, Инна ИосифовнаШматкова, Наталя ВолодимирівнаЗінченко, Оксана ЮріївнаСейфулліна, Інна ЙосипівнаShmatkova, Natalia V.Zinchenko, Oksana Yu.Seifullina, Inna Y.2018-02-082018-02-082017Вісник Одеського національного університету = Odesa National University Heraldhttps://dspace.onu.edu.ua/handle/123456789/12737Взаимодействием SnCl4 c изоникотиноилгидразонами R-бензойных альдегидов (R-HIb) в ацетонитриле синтезированы [SnCl4 (R-Ib∙Н)], где R=H (1), 4-Br (2), 4-NO2 (3), 2-OCH3 (4), 4-OCH3 (5), -ОC7 H15(6), а с гидразоном 2-OH-нафтойного альдегида (2-OH-H2 Inf) – [SnCl3 (2-OH-Inf∙Н)](9). Комплексы охарактеризованы методами массспектрометрии, кондуктометрии, термогравиметрии и ИК спектроскопии. Установлено влияние состава комплексов, природы заместителей (R) на активность в отношении Mycobacterium tuberculosis.Взаємодією SnCl4 з ізонікотиноїлгідразонами R-бензойних альдегідів (R-HIb) в ацетонітрілі синтезовані [SnCl4 (R-Ib∙Н)], де R=H (1), 4-Br (2), 4-NO2 (3), 2-OCH3 (4), 4-OCH3 (5), -ОC7 H15(6), а з гідразоном 2-OH-нафтойного альдегіду (2-OH-H2 Inf) – [SnCl3 (2-OH-Inf∙Н)](9). Сполуки охарактеризовані методами мас-спектрометрії, кондуктометрії, термогравіметрії та ІЧ спектроскопії. Установлено вплив складу комплексів, природи замісників (R) на активність щодо Mycobacterium tuberculosis.Сomplexes [SnCl4 (R-Ib∙Н)], where R=H (1), 4-Br (2), 4-NO2 (3), 2-OCH3 (4), 4-OCH3 (5), -ОC7 H15(6), were synthesized by interaction of SnCl4 with isonicotinoylhydrazones of R-benzoic aldehydes (R-HIb) in acetonitrile and complex [SnCl3 (2-OH-Inf∙Н)](9) – by interaction of SnCl4 with 2-OH- naphthaldehyde isonicotinoylhydrazone (2-OH-H2 Inf). In (1-6) bidentate O(C-O)–N(N=CH)-coordination of the enol form of the ligand is realized and the coordination node {SnCl4 ON}– is formed, and in (9) the enol form remains, but the composition of the node changes – {SnCl3 O2 N}– due to O(C-O)– N(N=CH)–О(Ph-O)- tridentate coordination. The compounds were characterized by the methods of elemental analysis, mass spectrometry, conductometry, thermogravimetry. Their structure was established by comparing the mass- and IR spectra (1-6) and (9) with previously obtained and X-ray structurally characterized complexes [SnCl4 (RIb∙Н)]∙CH3 CN (R=4-N(CH3 )2 (7)) and [SnCl3 (R-Ib∙Н)]∙2CH3 CN (R=2-OH(8)) with bi- (7) and tridentate coordination (8) of isonicotinoylhydrazones, respectively. It is shown that (1-6) and (9) are complex compounds of the zwitterionic type: the negative charge on the coordination nodes of tin(IV) is delocalized by the oxyazine fragment N=C–O, and the positive charge – by the protonation of the vacant pyridine nitrogen atom of hydrazide fragment. The influence of the composition of the coordination node of complexes (1-9), as well as the nature and position of the substituents (R) in their molecules on the activity against Mycobacterium tuberculosis was determined. It was found that the effect of complexes with tridentate hydrazones (8) and (9) on the growth of pathogen is lower (MIC = 12.5 and 25 μM/ml, respectively) compared with bidentate hydrazones (MIC (1-7) = 0,8 – 6,25 μM/ml), among which [SnCl4 (2-OCH3 -Ib∙Н)] (4) stand out (MIC = 0.8 μM/ml).ruтетрахлорид оловаSnCl4изоникотиноилгидразоныкомплексы Sn(IVминимальная ингибирующая концентрацияМИКMycobacterium tuberculosisстанум тетрахлоридSnCl4ізонікотиноїлгідразоникомплекси Sn(IV)мінімальна інгібуюча концентраціяМІКMycobacterium tuberculosistin tetrachlorideSnCl4isonicotinoylhydrazonesSn(IV) complexminimal inhibitory concentrationMICMycobacterium tuberculosisArticle