Перегляд за Автор "Khoma, Ruslan Ye."
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Документ Anti-influenza activity of the N-benzylaminomethansulphonic acid(2017) Khoma, Ruslan Ye.; Ennan, Alim-Abdul A.; Grydina, Tetiana L.; Radkevich, K. V.; Fedchuk, Alla S.; Lozitsky, Viktor P.; Хома, Руслан ЄвгенійовичThe influenza virus causes the greatest number of acute respiratory viral infections, which can lead to an exacerbation of chronic systemic diseases, to emergence of bacterial complications, to a significant deterioration of public health. But the majority of human isolates of influenza viruses rapidly become resistant to remantadine, oseltamivir. So, the creation of new effective anti-influenza agents is urgent task of medical science.Документ Anti-Influenza Activity of the N-Benzylaminomethansulphonic Acid(2017) Khoma, Ruslan Ye.; Ennan, Alim-Abdul A.; Grydina, Tetiana L.; Radkevich, K. V.; Lozitsky, Viktor P.; Хома, Руслан ЄвгенійовичThe influenza virus causes the greatest number of acute respiratory viral infections, which can lead to an exacerbation of chronic systemic diseases, to emergence of bacterial complications, to a significant deterioration of public health. But the majority of human isolates of influenza viruses rapidly become resistant to remantadine, oseltamivir.Документ Condensation of Acetamide in Aqueous Solutions in the Presence of Sulfur(IV) Dioxide(2009) Khoma, Ruslan Ye.; Mazepa, A. V.; Shestaka, A. A.; Ennan, Alim-Abdul A.; Gelmboldt, V. O.; Хома, Руслан ЄвгенійовичThe reactions leading to formation of cyclic structures are not typical for amides, in distinct to their thio analogs that under the conditions of acid catalyzed hydrolysis are prone to cyclization processes with formation of N,S-containing heterocycles [1–3].Документ Features of Interaction in the Sulfur(IV) Oxide–Hexamethylenetetramine–Water System: A First Example of Identification of the Product with a Sulfur–Carbon Bond(2011) Khoma, Ruslan Ye.; Shestaka, A. A.; Shishkin, O. V.; Baumer, Vyacheslav N.; Brusilovskiid, Yu. E.; Koroeva, L. V.; Ennan, Alim-Abdul A.; Gelmboldt, V. O.; Хома, Руслан ЄвгенійовичHexamethylenetetramine (HMTA) is a ligand in the synthesis of coordination compounds and also is used as a pharmaceutical antiseptic drug and as hexogen precursorДокумент Interaction of Sulfur Dioxide with Aqueous Solutions of Amides(2005) Khoma, Ruslan Ye.; Gavrilenko, M. I.; Nikitin, V. I.; Хома, Руслан ЄвгенійовичThe interactions in the systems H2O3Am3SO2 (Am is formamide, dimethylformamide, acetamide, urea, tetramethylurea, tert-butylurea) at 278 and 293 K were studied pH-metrically. The results suggest formation of intermolecular and ion3molecule associates. The composition and stability of the compounds formed strongly depend on the structure and concentration of the solution components and on temperature.Документ Methylammonium Sulfate: Synthesis and Structure(2015) Khoma, Ruslan Ye.; Gelmboldt, V. O.; Baumer, Vyacheslav N.; Puzan, A. N.; Ennan, Alim-Abdul A.; Хома, Руслан ЄвгенійовичThe reaction between sulfur(IV) oxide and aqueous methylamine yields “onium” sulfate (CH3NH3)2SO4, which was characterized by X ray diffraction, IR spectroscopy, and mass spectrometry. The structure of the sulfate is stabilized by a network of NH⋅⋅⋅O hydrogen bondsДокумент On Interaction of Sulfur(IV) Oxide with Aqueous Solutions of Ethanolamines(2012) Khoma, Ruslan Ye.; Shestaka, A. A.; Gelmboldt, V. O.; Хома, Руслан ЄвгенійовичPotentio- and conductometric titration was used to study the interaction in sulfur(IV) oxide– ethanolamines–water systems in comparison with the previously obtained pH-metric data on how the corresponding onium sulfi tes, hydrosulfi tes, and pyrosulfi tes are formed. The ionic and molecular compositions of these solutions were calculated. Correlations between the characteristics of pH-metric titration curves of aqueous solutions of ethanolamines with sulfur(IV) oxide and the relative stability of onium sulfates were revealed.Документ On Reaction of Sulfur Dioxide with Aqueous Solutions of Carbamide(2003) Khoma, Ruslan Ye.; Nikitin, V. I.; Gavrilenko, M. I.; Хома, Руслан ЄвгенійовичA mechanism of SO2 chemisorption by aqueous solutions of carbamide was suggested. The effective rate constants of accumulation of hydrogen ions in the reaction of sulfur dioxide with aqueous solutions of carbamide in the range 278 313 K were determined.Документ Onium Salts of Sulfur-Containing Oxyanions Resulting from Reaction of Sulfur(IV) Oxide with Aqueous Solutions of 1,2-Diamines and Morpholine(2017) Khoma, Ruslan Ye.; Gelmboldt, V. O.; Ennan, Alim-Abdul A.; Baumer, Vyacheslav N.; Puzan, A. N.; Koksharova, Tetiana V.; Mazepa, A. V.; Кокшарова, Тетяна Володимирівна; Хома, Руслан ЄвгенійовичReaction products have been isolated from SO2–L–H2O–О2 systems (L = ethylenediamine, N,N,N',N'-tetramethylethylenediamine, piperazine, and morpholine) as onium salts [H3NCH2CH2NH3]SO4, [(CH3)2NHCH2CH2NH(CH3)2]SO4, [(CH3)2NHCH2CH2NH(CH3)2]S2O6 ⋅ H2O, [C4H8N2H4]SO3 ⋅ H2O, [C4H8N2H4]S2O6, [C4H8N2H4]SO4 ⋅ H2O, [O(C2H4)2NH2]2SO4 ⋅ H2O. The prepared compounds have been characterized by X-ray diffraction analysis, X-ray powder diffraction, IR and mass spectroscopyДокумент Onium Sulfates and Hydrogen Sulfates: Products of Reactions of Sulfur(IV) Oxide with Aqueous Solutions of Alkylamines and Aniline(2018) Khoma, Ruslan Ye.; Gelmboldt, V. O.; Ennan, Alim-Abdul A.; Baumer, Vyacheslav N.; Rakipov, I. M.; Dlubovskiy, R. M.; Хома, Руслан ЄвгенійовичThe reaction products formed in the SO2–L–H2O–O2 systems (L is n-propylamine, n-butylamine, tert-butylamine, n-heptylamine, n-octylamine, aniline) were isolated and identified as “onium” salts [n-C3H7NH3]2SO4, [n-C4H9NH3]2SO4, [t-C4H9NH3]2SO4, [n-C7H15NH3]3SO4(HSO4), [n-C8H17NH3]3SO4(HSO4), and [C6H5NH3]2SO4. The products were characterized by elemental analysis, IR and Raman spectroscopy, mass spectrometry, and thermogravimetryДокумент Preparation and Some Physicochemical Properties of Benzylammonium Sulfates(2014) Khoma, Ruslan Ye.; Ennan, Alim-Abdul A.; Gelmboldt, V. O.; Shishkin, O. V.; Baumer, Vyacheslav N.; Mazepa, A. V.; Brusilovskii, Yu. E.; Хома, Руслан ЄвгенійовичNew method of preparation of multisubstituted benzylammonium cations via interaction in the SO2–L–H2O systems (L is benzylamine, α-phenylethylamine, N,N-dimethylbenzylamine, or dibenzylamine) has been developed. The products have been studied by X-ray diffraction, IR, Raman spectroscopy, and mass spectrometry.Документ Products of Interaction between Sulfur(IV) Oxide and Aqueous Solutions of Hexamethylendiamine and tert Butylamine: The Crystal Structure of Hexamethylenediammonium Sulfate Dihydrate(2012) Khoma, Ruslan Ye.; Ennan, Alim-Abdul A.; Shishkin, O. V.; Baumer, Vyacheslav N.; Gelmboldt, V. O.; Хома, Руслан ЄвгенійовичThe possibility of mild SO2 oxidation in sulfur(IV) oxide–alkylamine–water–oxygen systems is demonstrated to yield onium sulfatesДокумент Products of interaction of sulfur dioxide with amines in aqueous solutions. Effect of amines basicity and lipophilicity on the compounds composition(2017) Khoma, Ruslan Ye.; Хома, Руслан ЄвгенійовичReaction products have been isolated from SO2 – L – H2O – О2 systems (L = alkylamines, benzylamines, ethanolamines, aniline, 2,2′-bipyridine and their deravatives). The prepared compounds have been characterized by elemental analysis, X-ray diffraction analysis, X-ray powder diffraction, IR, Raman spectroscopy, 1H, 13C NMR, and mass spectrometry, thermogravimetry.Документ The products of SO2 interaction with aqueous solutions of methylamine, benzylamines, 1,2-diamines and morpholine(2015) Khoma, Ruslan Ye.; Gelmboldt, V. O.; Ennan, Alim-Abdul A.; Baumer, Vyacheslav N.; Mazepa, A. V.; Koksharova, Tetiana V.; Кокшарова, Тетяна Володимирівна; Хома, Руслан ЄвгенійовичThe new method of preparation of sulphuroxoanions “onium ” salts via interaction in the SO 2- L -H2O -O2 systems (L. is methylamine, bonzylamines, 12 -diamines, and morpholine) has been developed. Onium sulfates have been obtained from methylamine, benzylamine, a-phcnylethylamine, N,N -dimethylbenzylamine, dibenzylamine, 1 ,2-ethylenenediamine, morpholine, N,N,N\N3- tetramethylethylenediamine; sulphitesmonohyd rates - from piperazine and N -(hydroxyethyl)ethylenediamine; dithionate - from piperazine and N,N,N\N 3-tetramethylethylenediamine. The compounds were characterized by elemental analysis, X-ray diffraction, IR, Raman spectroscopy, mass spectrometry, and differential thermal analysis.Документ A Study of Complexation in the System Constituted by Water, Carbamide, and Sulfur Dioxide at 293 K(2004) Khoma, Ruslan Ye.; Gavrilenko, M. I.; Nikitin, V. I.; Хома, Руслан ЄвгенійовичElectronic absorption spectroscopy and potentiometry were applied to study complexation at 293 K in a system constituted by water, carbamide, and sulfur dioxide. The composition and stability of the molecular and ionic complexes formed was determined in relation to the concentration of components in solution.Документ Synthesis and Structure of Aminoguanidinium Sulfite Monohydrate(2013) Khoma, Ruslan Ye.; Gelmboldt, V. O.; Baumer, Vyacheslav N.; Shishkin, O. V.; Koroeva, Larysa V.; Хома, Руслан ЄвгенійовичThe reaction between sulfur(IV) oxide and an aqueous suspension of aminoguanidinium hydro carbonate yields (CN4H7)2SO3 ⋅ H2O, an “onium” sulfite, which has been characterized by X ray diffraction and IR spectroscopy and mass spectrometry. The structure of the salt is stabilized by numerous H bonds, such as NH⋅⋅⋅O, OH⋅⋅⋅O, and NH⋅⋅⋅N. The incorporation of pyramidal ions into the network of H bonds is accompanied by the lowering of their symmetry in comparison with C3v, thus complicating the IR spectra of the salt in the region where the vibrations of the anion appear.Документ Synthesis and Structure of N (Hydroxyethyl)ethylenediammonium Sulfite Monohydrate(2014) Khoma, Ruslan Ye.; Gelmboldt, V. O.; Shishkin, O. V.; Baumer, Vyacheslav N.; Puzan, A. N.; Ennan, Alim-Abdul A.; Rakipov, I. M.; Хома, Руслан ЄвгенійовичA reaction between sulfur(IV) oxide and aqueous N (2 hydroxyethyl)ethylenediamine yields onium sulfite of composition (HOCH2CH2NH2CH2CH2NH3)SO3 ⋅ H2O, which has been characterized by X ray diffraction, IR spectroscopy, and mass spectrometry. The three dimensional structure of the salt is sta bilized by numerous hydrogen bonds, such as NH⋅⋅⋅O and OH⋅⋅⋅O.Документ Synthesis, Crystal Structure, Vibrational Spectra, and Thermochemical Transformations of Tris(hydroxymethyl)aminomethane(2014) Khoma, Ruslan Ye.; Gelmboldt, V. O.; Shishkin, O. V.; Baumer, Vyacheslav N.; Ennan, Alim-Abdul A.; Хома, Руслан ЄвгенійовичA practically promising compound, tris(hydroxymethyl)aminomethane sulfate ((TRISH)2SO4, C8H24N2O10S) was synthesized and studied by a set of experimental methods (elemental analysis, IR and Raman spectroscopy, mass spectrometry, thermogravimetry).Документ Synthesis, Spectral Characteristics, and Some Properties of Methylammonium Sulfamate Monohydrate. A New Route to Sulfamic Acid Derivatives(2010) Khoma, Ruslan Ye.; Mazepa, A. V.; Gelmboldt, V. O.; Shestaka, A. A.; Koroeva, L. V.; Tsapko, M. D.; Ennan, Alim-Abdul A.; Хома, Руслан ЄвгенійовичRedox transformations of the products of reactions of the CH3C(S)NH2–SO2–H2O system components yield methylammonium sulfamate monohydrate [CH3NH3]+[OSO2NH2]– ⋅ H2O and elemental sulfur. The synthesized compound was characterized by IR, 1H and 13C NMR, and mass spectroscopy and some of its properties were studied.Документ Toxicity and antiviral action of the aminomethanesulphonic acid and its N-alkylated derivatives(2016) Khoma, Ruslan Ye.; Ennan, Alim-Abdul A.; Godovan, V. V.; Antonenko, P. B.; Grydina, T. L.; Fedchuk, Alla S.; Lozitsky, Viktor P.; Хома, Руслан ЄвгенійовичThe influenza is the most mass disseminated viral disease of the human respiratory. The purpose of this study is to research toxicity and antiviral activity of the aminomethanesulphonic acid (I) and its N-methyl (II), N-tert-butylderivatives (III) and reference drug (Tamiflu). We have determined the maximally tolerant (non-toxic) doses (MTD) for these compounds. Oral LD50 of I – III: > 5000 mg/kg (rat, male) – practically non-toxic. On tissue culture CAC influenza activity was determined in a dose of 10-3 M as for test compounds so for the reference drug (Tamiflu).