Fatty acid profiles in planktonic and bi ofi lm P. aeruginosa cells with different level of c-di-GMP
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2018
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Анотація
Pseudomonas aeruginosa is a Gram-negative pathogen responsible for a variety of opportunistic infections,
including chronic airway infections in patients with cystic fibrosis (CF). During the course
of chronic infection, P. aeruginosa forms matrix-encased, surface-associated communities called
biofilms. Biofilms are thought to contribute to persistence in the CF airway by contributing to evasion
of the host immune response and antimicrobial therapy. Biofilm communities differ from planktonic
bacterial cultures not only in terms of their metabolic activity but they also display stage-specific
phenotypes during development and considerable spatial heterogeneity of physiological condition.
Cells alter the fatty acid composition of their lipids to maintain membrane fluidity with varying
environmental conditions. In this study, fatty acid profiles of biofilms versus planktonic cells of the
P. aeruginosa with different level of intracellular c-di-GMP were compared.
Опис
Ключові слова
Pseudomonas aeruginosa, c-di-GMP, metabolic activity
Бібліографічний опис
The Ukrainian biochemical journal