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|Title:||ZnO thin films as a platform for optical immunosensors devoted for determination of GVA-antigen|
|Authors:||Tereshchenko, Alla V.|
Smyntyna, Valentyn A.
Konup, Ihor P.
Конуп, Ігор Петрович
Конуп, Игорь Петрович
Терещенко, Алла Володимирівна
Терещенко, Алла Владимировна
|Citation:||Advances in Bioelectrochemistry and Nanomaterials [Электронный ресурс] : book of abstracts of the 9th Nanoconference (20th-22nd October 2016) / Vilnius University (VU) . – Электрон. кн. – Vilnius, 2016|
Grapevine virus A-type (GVA)
thin films of ZnO
|Abstract:||Optical immunosensor for the determination of Grapevine virus A-type (GVA) proteins (GVAantigens) has been developed . The immunosensor was based on thin films of ZnO (100 nm thickness) formed by atomic layer deposition (ALD). The ZnO-based films have demonstrated good surface-structural properties for the absorption of antibodies (anti-GVA) against GVAantigens in order to form a biosensitive layer. The absorption of anti-GVA antibodies resulted in new photoluminescence band appearance in the region of 400-550 nm that can be caused by the formation of some chemical bounds during the anti-GVA adsorption on ZnO surface . The possibility to detect GVA-antigens without additional labels (e.g enzymes or fluorescent dyes) has been demonstrated. The GVA-antigen detection was performed by the evaluation of changes and behavior of the photoluminescence band, related to protein adsorption (Fig. 1). The sensitivity of as-formed label-free biosensor towards the GVA-antigens was determined in the range from 1 pg/ml to 10 ng/ml; in addition, the selectivity of biosensor was evaluated|
|Appears in Collections:||Статті та доповіді ФМФІТ|
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